The Coxsackie Viruses

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The Coxsackie viruses.

Coxsackie is a village on the banks of the Hudson River in upper New York State. In the course of investigating an outbreak of poliomyelitis there, Dalldorf and Sickles (1948) isolated a hitherto unrecognized filterable agent from the faeces of two children with lower limb paralysis. Neutralizing antibodies for this new virus appeared in the blood of both patients during convalescence. Attempts...

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Coxsackie viruses and diabetes mellitus.

Serum specimens from 162 patients with insulin-dependent diabetes of recent onset and 319 controls were tested for neutralizing antibodies to Coxsackie viruses types B1 to B5. Antibody to type B4 virus was more often found in diabetics than in controls, particularly in the 10-19 year age group. Though controls were not matched for geographical area it was thought that this was unlikely to expla...

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Immunological Reactions of the Coxsackie Viruses

Maternal antibodies to the Coxsackie viruses (C virus) are conveyed to newborn mice through the colostrum and milk. of vaccinated mothers. No evidence for or against placental transmission of immunity was obtained. The immunity conferred on the young is type-specific. Immunity may be conferred to infants born of non-immune mice by allowing a suckling period of 24 to 48 hours with an immune moth...

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Neuropathogenicity of Group a Coxsackie Viruses

Coxsackie virus, Group A, Type 14, has been adapted to adult mice and monkeys and induces in them poliomyelitis-like lesions and, in the case of the mice, flaccid paralysis.

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Comparative genomics of the coxsackie B viruses and related enteroviruses.

Genomic analysis of the group B coxsackieviruses (CVB) has improved our understanding of CVB evolution, epidemiology, and pathogenesis. Comparison of capsid sequence alignments and virion structures allows correlation of capsid diversity with surface features, such as loops, the receptor canyon, and antigenic sites. Pairwise sequence comparisons and phylogenetic analyses can be used to rapidly ...

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ژورنال

عنوان ژورنال: American Journal of Public Health and the Nations Health

سال: 1950

ISSN: 0002-9572

DOI: 10.2105/ajph.40.12.1508